Alan
My 12 year old Westie also became extremely aggressive after two months on Apoquel. Four days off the drug, he is returning to his normal self. We will deal with the skin issues another way.
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Will Falconer, DVM Moderator
Really interesting, H. I wonder if, in addition to its known effects on suppressing immunity, Apoquel also creates gut dysbiosis. As you likely know, the gut-brain axis is well established, so behaviors can change when the flora gets disrupted. You're one of a handful who've brought behavioral changes after using this drug to my attention. Likely more need to watch for this and report in, especially if they are periodic, on/off users of Apoquel.
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