Will Falconer, DVM Moderator
Oh, Ronda, what a heart rending story! Having lived in Hawaii for several years, and studying the quarantine system, I know your dogs were likely multiply vaccinated before they arrived at their new home.
That, plus this drug, sent your Shepherd into a dangerous immune spiral that she simply couldn't pull out of. I'm so sorry you lost her.
The good news for the survivors is two fold: you needn't vaccinate again (and shouldn't!). No rabies law there, and they are now immune for life (review my Vaccine: Efficacy and Vaccine: Safety pages to ground yourself in this understanding).
And second, I kept HW away from my patients both in Hawaii and her in Texas (and Florida, and other states known to have the parasite) with my Drug Free HW Prevention Program. So, get that going and don't risk another dose of the Trifexis.
I wish you all the best. It's such a stress just moving to a totally different place on the planet, but adding the heartache of losing a family member in the mix makes it ever so much more challenging.